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The HKU E-learning Platform in Clinical Medicine
The HKU E-learning Platform in Clinical Medicine
  • Physical Examination Skills
    • General Examination
    • Examination of the Cardiovascular System
    • Examination of the Gastrointestinal System
    • Examination of the Neurological System
    • Examination of the Respiratory System
    • Examination of the Musculoskeletal System
    • Demonstration on putting on a surgical/ N95 mask properly
  • eLearning Materials of Individual Divisions
    • Cardiology
    • Clinical Pharmacology
    • Dermatology
    • Endocrinology
    • Gastroenterology & Hepatology
    • Geriatrics
      • Common Physical Signs in the Geriatric Setting
      • Commonly used Assessments in the Geriatric Setting
    • Haematology
    • Infectious Diseases
    • Nephrology
      • General Nephrology
      • Imaging
      • Peritoneal Dialysis
      • Hemodialysis
    • Neurology
    • Rehabilitation Medicine
      • Modified Ashworth Scale
      • Complex Regional Pain Syndrome
      • Case 1
      • Case 2
    • Respiratory Medicine
    • Rheumatology
      • Common Rheumatological Cases
      • Clinical Signs and Radiographs of Patients with Rheumatological Disorders
  • Credits
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Nephrology
General Nephrology

Alport’s Syndrome

July 10th, 2015

Alport’s Syndrome

Courtesy of Dr. KW Chan and Dr. G. Chan, Department of Pathology, Queen Mary Hospital

This electron microscopy photo was from a patient with Alport’s syndrome. There is irregular thickening of the glomerular basement membrane as well as splitting and basket-weave appearance of lamina densa (arrow).

Alport’s syndrome is caused by mutations in the Type IV collagen of the basement membrane. The mode of inheritance is usually X-linked recessive. Patients commonly present with renal failure and hearing impairment during their teenage years.

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